Medical review: Dr. Walter Zamarian Jr. – plastic surgeon in Londrina, Brazil, CRM-PR 17.388, RQE 15.688, full member of the Brazilian Society of Plastic Surgery (SBCP) and member of the American Society of Plastic Surgeons (ASPS). Last reviewed on May 22, 2026.
Dr. Zamarian has 20+ years of medical experience and 8,000+ surgeries performed, with a focused practice in Deep Plane facelift, neck lift, facial fat grafting and advanced facial rejuvenation planning.
A facelift can reposition deeper facial structures, improve jowls and redefine the jawline, but it does not erase every surface change in the skin. Laser resurfacing, PRP, facial fat grafting and nanofat can be useful adjuncts in selected patients because they target different problems: texture, pigmentation, fine lines, tissue quality or selected volume loss.
The important point is hierarchy. The Deep Plane facelift remains the structural procedure; complementary treatments are not a shortcut, not a substitute for surgery and not a guarantee of “skin regeneration.” They are tools that should be selected after examination of skin thickness, sun damage, pigmentation risk, volume loss, healing profile and expectations.
Short answer: Complementary treatments are worth considering when the facelift plan needs more than lifting alone, but they should be recommended individually rather than sold as a universal package.
What each adjunctive treatment is meant to do
Laser resurfacing
Laser resurfacing acts on the skin surface and upper dermis. In the right patient, fractional CO2 or erbium resurfacing can improve fine lines, sun damage, pigmentation irregularity and uneven texture. It is most useful for concerns around the mouth, lower eyelids and photodamaged skin that a facelift cannot directly correct.
Laser timing matters. In some patients it can be performed conservatively during the same operative plan; in others it is safer to stage it weeks or months later, especially when deeper resurfacing is needed or when pigmentation risk is higher.
PRP
PRP, or platelet-rich plasma, is prepared from a small sample of the patient’s own blood and contains platelet-derived signaling factors. It may support tissue recovery and skin quality in selected settings, but the clinical evidence for facial rejuvenation is still limited and variable. PRP should not be described as a guaranteed way to accelerate healing or improve the final facelift result.
Facial fat grafting
Facial fat grafting is used when aging includes volume loss in areas such as the temples, cheeks, tear trough region or jawline transition. It can complement a facelift because lifting and volume restoration solve different parts of facial aging. Fat graft survival varies, swelling is expected and small irregularities or asymmetries are possible, so the indication must be precise.
Nanofat
Nanofat is processed fat used mainly for skin-quality goals rather than volume restoration. It is best discussed as a biologic adjunct with evolving evidence, not a guaranteed stem-cell therapy. Some studies suggest possible benefits for texture, scars and skin quality, but results vary and the literature is not strong enough to promise collagen gain, permanent rejuvenation or predictable skin transformation.
How these treatments fit with a Deep Plane facelift
A Regenerative Deep Plane facelift approach starts with structural correction: the deeper mobile tissues are repositioned, the midface and jawline are restored and the neck is assessed as part of the same aesthetic unit. Adjuncts are then considered only if they solve a specific remaining layer of the problem.
For example, a patient with jowling and neck laxity may need a facelift and neck lift more than any skin treatment. A patient with strong sun damage may benefit from staged laser resurfacing. A patient with a hollow cheek or temple may need fat grafting. A patient with thin or crepey lower eyelid skin may need a careful plan that also considers blepharoplasty, resurfacing or fat grafting depending on the anatomy.
When I would stage treatment instead of combining everything
Staging can be the safer and more elegant choice. Laser resurfacing may be staged when the skin has been widely undermined, when deeper settings are planned, when pigmentation risk is relevant or when the patient cannot manage a longer recovery period. Fat grafting can be staged when swelling would make judgment less precise. PRP may be repeated later if the goal is supportive skin care rather than a one-time operative adjunct.
Combining procedures is not a badge of sophistication. The better question is whether each element improves the plan without adding unnecessary risk, downtime or cost.
Risks and limitations
Every facelift involves surgical risk. Important risks include bleeding or hematoma, infection, anesthesia complications, delayed wound healing, skin suffering, numbness, prolonged swelling, visible scarring, hairline changes, facial nerve weakness, asymmetry and the possibility that revision surgery may be needed. These issues should be discussed directly during consultation and consent.
Adjunctive treatments add their own risk profile. Laser resurfacing can cause prolonged redness, pigmentation change, infection, acne flare, delayed healing or scarring. PRP can cause swelling, bruising or discomfort and its aesthetic benefit is not predictable. Fat grafting and nanofat can cause swelling, contour irregularity, asymmetry, oil cysts or partial resorption.
Patients with active infection, uncontrolled diabetes, smoking, poor wound-healing history, unrealistic expectations or higher pigmentation risk may need a modified plan or may not be good candidates for certain adjuncts.
Recovery when treatments are combined
Recovery depends on the most intensive part of the plan. PRP alone usually adds little visible downtime. Fat grafting and nanofat add swelling and bruising, especially around the cheeks or eyelids. Laser resurfacing can add redness, peeling, crusting and strict sun avoidance, and recovery length depends on the device, depth and treated area.
Most facelift patients need a structured recovery plan with rest, incision care, activity restriction and close follow-up. When resurfacing is included, skin care instructions and sun protection become even more important.
Frequently asked questions
Are laser, PRP and nanofat always worth adding to a facelift?
No, laser, PRP and nanofat are worth adding only when they solve a specific problem that surgery alone does not address. A facelift treats structural descent; adjuncts are considered for skin texture, sun damage, selected volume loss or tissue-quality goals.
Can laser resurfacing be done at the same time as a facelift?
Laser resurfacing can sometimes be performed with a facelift, but timing depends on skin undermining, laser depth, skin type, pigmentation risk and healing profile. Staging the laser after surgery is often safer when a more aggressive resurfacing result is desired.
Does PRP make facelift recovery faster?
PRP may support healing biology in selected patients, but it should not be promised as a guaranteed way to speed recovery. The evidence for facial rejuvenation is still variable, and recovery is mostly determined by surgical extent, patient health and postoperative care.
Is nanofat the same as stem-cell therapy?
No, nanofat should not be marketed as predictable stem-cell therapy. It is processed autologous fat used as a biologic adjunct, and while early studies suggest possible skin-quality benefits, outcomes remain variable and should be discussed responsibly.
What is the best combination for facial rejuvenation?
The best combination is the smallest plan that addresses the patient’s real anatomy: structural lifting when tissues have descended, fat grafting when volume is deficient, resurfacing when the skin surface is damaged and conservative adjuncts only when they add value.
Evidence note: This article follows a conservative interpretation of patient-safety guidance from the American Society of Plastic Surgeons and Mayo Clinic, and of current literature on PRP, nanofat and adjunctive facelift procedures. The goal is not to sell a package, but to explain which layer of facial aging each treatment may address.
Considering a facelift in Brazil? The safest way to decide whether laser, PRP, fat grafting or nanofat belongs in your plan is a detailed medical consultation with facial analysis, health review and discussion of realistic goals.
Schedule an online consultation or read more about the Deep Plane facelift in Brazil.




